This dog-calming treat for hyper dogs aids the nervous system by reducing stress and tension and calming hyperactive behavior. Particularly useful in stressful situations like thunderstorms, travel, fireworks, separation anxiety, or trips to the vet. The combo of thiamine and l-tryptophan helps reduce stress and tension. Thiamine (B1) is water soluble and has calming properties. L-tryptophan increases levels of serotonin in the brain, a calming neurotransmitter. Included in this unique Chew + Heal formula are ginger and chamomile which help settle the stomach and are often used to ease indigestion for pets. This is especially helpful for road trips and traveling. Melatonin is a naturally produced hormone that helps regulate sleep and wake cycles and promotes rest and relaxation. Chamomile is a plant extract used for sleepiness, and passion flower is used for relaxation, to soothe tension, and stress relief. Give the best dog calming chews for anxiety approximately 30 minutes before the stressful situation commences. Designed for dogs over 12 weeks, check the product package for the suggested dosage for your size pet.